1038915-60-4 Niraparib un nuovo inibitore della polimerasi Orale Poly (ADP-ribosio) (PARP) efficace nei tumori mutanti BRCA-1 e -2.

Model No.
1038915-60-4
temp. di stoccaggio
+25ºc
requisiti di qualità
controllo di qualità rigoroso
Pacchetto di Trasporto
25kg/Drum/1000g/Bag/10g/Bag
Specifiche
100% raw material
Marchio
Widely
Origine
China
Capacità di Produzione
1000 kg/mon
Prezzo di riferimento
$ 13.50 - 45.00
contattaci

Descrizione del Prodotto

1038915-60-4 Niraparib a Novel Oral Poly (ADP-ribose) Polymerase (PARP) Inhibitor Efficacious in Brca-1 and -2 Mutant Tumors.
Uses Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Description (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide is also known as MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 (The poly(ADP-ribose) polymerase) with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It has been recently approved by FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death.
Uses Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Pharmacology The synthesis and initial pharmacology of niraparib have been published. Niraparib has affinity for PARP 1 and 2 inhibition (IC50 = 3.8 and 2.1 nM, respectively) and inhibits the proliferation of cancer cells with mutant BRCA1 and BRCA2 with IC50 values in the 10-100 nM range in vitro. Niraparib demonstrated efficacy as a single agent in a xenograft model of BRCA1-deficient cancer. Niraparib has also been reported to act as a preclinical radiosensitiser and has entered into clinical oncology trials.
 
1038915-60-4 Niraparib a Novel Oral Poly (ADP-ribose) Polymerase (PARP) Inhibitor Efficacious in Brca-1 and -2 Mutant Tumors.
1038915-60-4 Niraparib a Novel Oral Poly (ADP-ribose) Polymerase (PARP) Inhibitor Efficacious in Brca-1 and -2 Mutant Tumors.
Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.

The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.

With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.

Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.


I. Do you always have this products in stock?
Our company has more than 1000 kinds of products in stock. We usually have them 
in stock. We can show you the information, forms or pictures of our warehouse 
at any time. If the stock is insufficient, our company will replenish them as 
soon as possible according to the ERP system.

2. What certificates and documents do you offer?
According to the situation of products, we can provide COA, NMR, LC, MS, 
synthesis process, MQA, MSDS, etc

3. Why should I choose you?
Stock in stock and deliver in time
Reasonable price
Product technology and data support
Professional sales team
Perfect pre-sale and after-sale service

4. Can I get best price from you?
We don* t pursue expensive profits
We always try to give best offer
You can also enjoy fun of bargaining

5. How should I pay?
T/T bank transfer West union PayPal
 

 

Altri Medicine

SUPERAUTO.CAT, 2023